X-Inactivation: Xist RNA Uses Chromosome Contacts to Coat the X
نویسندگان
چکیده
The mechanisms by which Xist RNA associates with the X chromosome to mediate alterations in chromatin structure remain mysterious. Recent genome-wide Xist RNA distribution studies suggest that this long noncoding RNA uses 3-dimensional chromosome contacts to move to its sites of action.
منابع مشابه
X-chromosome inactivation: the molecular basis of silencing
X-chromosome inactivation occurs randomly for one of the two X chromosomes in female cells during development. Inactivation occurs when RNA transcribed from the Xist gene on the X chromosome from which it is expressed spreads to coat the whole X chromosome. In the first issue of Epigenetics and Chromatin, Nesterova and colleagues investigate the role of the RNA interference pathway enzyme Dicer...
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عنوان ژورنال:
- Current Biology
دوره 24 شماره
صفحات -
تاریخ انتشار 2014